Detecting Gene-Gene Interactions for Cleft Lip with/without Cleft Palate in Targeted Sequencing Data
نویسندگان
چکیده
منابع مشابه
Role of SOX9 in the Etiology of Pierre-Robin Syndrome
Objective(s:Cleft lip/palate are common congenital anomalies, affecting approximately 2/1000 live births. Pierre Robin Sequence is a subgroup of the cleft palate population. Chromosomal abnormalities near the SOX9 gene disrupt the regulation of this gene and prevent the SOX9 protein from properly controlling the development of facial structures, which leads to isolated PRS. The present study wa...
متن کاملEvaluation of Receptive and Expressive Vocabulary in 6-18 Month’s-old Children With Cleft Lip and Palate
Objectives: One of the factors predicting language impairments is an early limited lexicon in children. An early limited lexicon can also lead to limited performances in other language areas. This study was aimed to examine receptive and expressive vocabulary in 8-16 month-old children with cleft lip and palate as a predictor of development in other language areas. Materials: The MacArthur-Bat...
متن کاملThe Prevalence of Different Types of Cleft Lip and Palate and Related Factors Among Newborns in North Khorasan Province, 2016 - 2017
Introduction: Cleft lip/palate is the most prevalent congenital anomaly of the head and neck area. This problem has a multifactorial nature and the causing factors have not yet been fully known. 60 percent of cleft lip is accompanied with cleft palate. The prevalence rate of this anomaly is estimated 1 in 700 people due to several studies. Methods: In this cross-sectional study data of the neon...
متن کاملIdentification of a novel heterozygous truncation mutation in exon 1 of ARHGAP29 in an Indian subject with nonsyndromic cleft lip with cleft palate
OBJECTIVE Mutations in exon 1 of ARHGAP29, a RhoA specific GTPase have been identified in North American and Filipino subjects with nonsyndromic cleft palate and cleft lip with or without cleft palate. Since the genetic status of ARHGAP29 in Indian subjects with nonsyndromic oral clefts is not known, we designed the present study to investigate the occurrence of the above mutations in them. M...
متن کاملEffects of Tongue Plate on the Nasomaxillary Complex of Patients with Unilateral Cleft Lip and Cleft Palate
Background and aim: Cleft lip and cleft palate are among the most common orofacial abnormalities. Patients with these deformities commonly present with midface deficiency and need challenging treatment modalities that focus on improving the position of the maxilla. Tongue plate appliance is an intraoral device that has shown promising results in the treatment of growing patients with maxillary ...
متن کامل